Basic Info.
Application
Internal Medicine
Suitable for
Elderly, Adult
Pharmaceutical Technology
Chemical Synthesis
Product Name
Bupleurum Injection
Specification
2ml per stick
Product Description
Product name: Bupleurum InjectionPharmaceutical ingredients: The volatile oil of Northern Caulophyllum or Narrow-leaved Caulophyllum. Radix Bupleurum Chinense root (coarse powder) 1000g, sodium chloride 9g, Tween-80 60ml.Character: This product is a colorless to slightly yellow or slightly milky white clear liquid; aromatic.Indications: Relieving and reducing fever. It is used for cold, flu and other upper respiratory tract infections. Shuguang Hospital affiliated to Shanghai College of Traditional Chinese Medicine used this product to observe the clinical efficacy of 64 cases of acute upper respiratory tract infection with cold and fever, and the results showed that the total effective rate of this product was 75% to 80%. It can also reduce the accompanying symptoms without obvious side effects. The conclusion is that the fever is reduced smoothly, there is no rebound after cooling, and the patient recovers faster after the disease.Usage and Dosage:Injection: 2-4ml each time, 1-3 times a day intramuscularly; reduce as appropriate for children.
Nasal drops: 0.3-0.5ml per time for children, 0.5-0.8ml per time for adults.Adverse reactions:Bupleurum Injection can cause anaphylactic reactions; anaphylaxis; fixed drug rash.
Adverse reactions of this product include anaphylaxis, which should be used in medical institutions with resuscitation conditions, and users should be trained in anaphylaxis resuscitation, and allergic reactions or other serious adverse reactions after use must be discontinued immediately and rescued promptly.
Allergic reactions: flushing or pale skin, rash, itching, dyspnea, palpitations, cyanosis, drop in blood pressure, anaphylaxis, anaphylaxis-like reactions, etc.
Systemic reactions: chills, chills, fever, pain, malaise, etc.
Skin and its adnexa: a variety of rashes may be manifested, with urticaria and dermatitis with pruritus predominating.
Respiratory system: breath-holding, shortness of breath, dyspnea, etc.
Cardiovascular system: palpitations, chest tightness, cyanosis, decreased blood pressure, etc.
Neuropsychiatric system: dizziness, headache, numbness, vertigo, syncope, convulsions, blurred consciousness, etc.
Digestive system: dry mouth, nausea, vomiting, abdominal pain, diarrhea, etc.
Medication site: pain, rash, itching, local redness, swelling and hard nodes, etc.Taboo: 1. Contraindicated in persons with hypersensitivity or history of serious adverse reactions to this product or to preparations containing Chai Hu and the excipients listed in the ingredients.
2. Contraindicated in children.Matters needing attention:1. Adverse reactions of this product include anaphylaxis, which should be used in medical institutions with resuscitation conditions, and users should be trained in anaphylaxis resuscitation, and allergic reactions or other serious adverse reactions should be discontinued immediately and treated promptly after use.
2. Strictly in accordance with the drug instructions specified in the main function of the use, prohibit the use of drugs beyond the main function.
3. This product is an antipyretic and antihypertensive drug and is not recommended for people without fever.
4. Strictly follow the dosage recommended in the drug's instruction manual, especially pay attention not to overdose and not to use the drug continuously for a long time.
5. The patient's condition, medication history and allergy history should be carefully inquired before administration. Use with caution if you have a history of drug allergy or an allergic body.
6. Use with caution if you have a family history of allergy.
7. Improper storage of this product may affect the quality of the drug, the product should be carefully checked before use, and should not be used if the liquid is found to be cloudy, precipitated, discolored, crystallized and other changes in drug properties, as well as if there are air leaks and cracks in the bottle.
8. Mixing and combining is strictly prohibited. This product should be used alone and is not to be mixed with other drugs.
9. Special populations such as the elderly, pregnant women, patients with abnormal liver and kidney functions, and patients who are using Chinese medicine injections for the first time should be used with caution and monitoring should be strengthened.
10. Strengthen medication monitoring. During medication administration, the reaction to medication should be closely observed, especially the first 30 minutes. If abnormalities are found, stop the drug immediately and use active rescue measures to save the patient.
Pharmacological effects:It has mainly antipyretic, anti-inflammatory and immune-enhancing effects.
1. Antipyretic effect: Intraperitoneal injection of 300mg/kg of the total volatile oil of Radix Bupleurum has a significant antipyretic effect on the fever caused by brewer's yeast suspension in rats. The hypothermic effect of intra-ear injection of 20ml/kg of C. cypress on fever caused by typhoid and paratyphoid vaccines in rabbits was not significantly different from that of the control group. Although intraperitoneal injection of Bupleurum Injection 10mg/kg had a cooling effect on the fever caused by brewer's yeast in rats, there was no significant difference compared with the saline control group. The ear intravenous injection of Bupleurum Injection 3mg/kg had a significant cooling effect on the fever caused by triple vaccine (pertussis, diphtheria and tetanus vaccine) in rabbits.
2. Anti-inflammatory: When the total volatile oil of C. nilotica was injected intraperitoneally at 40mg/kg and 240mg/kg, only the former dose had a significant anti-inflammatory effect on the swollen feet of rats with carrageenan. The ear intravenous administration of 5.0 ml/kg of C. cypress injection had an antagonistic effect on the increase of skin permeability caused by xylene in rabbits, but there was no significant difference compared with the control group. Intraperitoneal injection of Bupleurum Injection 5.0 ml/kg had an inhibitory effect on foot swelling and cotton ball granulomatous swelling in scalded rats, but it was not statistically significant.
3. Enhancement of immune function: Continuous intraperitoneal injection of Bei Chai Hu 0.25ml/day had a significant promotion effect on the formation of anti-sheep erythrocyte antibodies in secondary immunized mice; intraperitoneal injection of Bei Chai Hu had no significant effect on the production of anti-tetanus toxoid in four times immunized rabbits, and had a significant enhancement effect on the inhibition of leukocyte movement.Drug Interaction:
There is no information on the interaction of this product with other drugs.Clinical Applications:
1. Pediatric fever: apply this formula orally, 1ml for age less than 6 months, 2ml for age 6 months to 1 year, 3ml for age 1-3 years, 4ml for age 3-7 years. body temperature greater than 40ºC plus physical cooling (40% alcohol external rub). We treated 128 cases of pediatric fever, 48 cases aged less than 1 year, 50 cases aged 1-3 years, and 30 cases aged 3-7 years; 46 cases with body temperature 38.5-39ºC, 67 cases with temperature 39.1-40ºC, and 15 cases with temperature greater than 40ºC. Results: A 1.5ºC drop in body temperature in the first hour after taking this formula orally was considered effective in 94 cases; a 1.5ºC drop in the second hour was considered effective in 30 cases; a drop in body temperature after 2 hours or no drop was considered ineffective in 4 cases; the total effective rate was 96.9%.
2. Flat warts: choose the mother warts, routine disinfection of the skin, with sterile syringes and skin test needles to draw Chaihu injection, from the edge of the mother warts into the needle to the base of the back draw no blood back that is injected into the drug, depending on the size of the rash each shot 0.2-0.5ml, to the wart body white can be. The actual fact is that the actual actual person is not a person who is not a person. The treatment of flat warts 39 cases, 11 male, 28 female; age 9-40 years; disease duration of 6 months to 9 years. Results: 35 cases were cured (all warts disappeared), accounting for 89.7% (9 cases were cured after 1 injection, 18 cases after 2 injections, and 8 cases after 3-4 injections); 4 cases were effective (warts were smaller, flatter, and partially disappeared than the original), accounting for 10.3%. The original lesions than the reduction of 1/2 of the 3 cases, l/3 of the 1 case, all cases are effective.
3. Mumps: Different doses of Chai Hu injection were given according to the age of the patients, 2ml each time for those younger than 10 years old and 4ml each time for those older than 10 years old. 1 time daily, 3-4 times in a row, do not use other drugs. We treated 38 cases of mumps, 22 males and 16 females; the youngest was 5 years old and the oldest was 35 years old, with an average age of 12.7 years. The diagnostic criteria were: history of exposure to mumps; bilateral or unilateral swelling (diffuse swelling centered on the earlobe) and pain in the parotid glands; redness and swelling visible at the opening of the parotid glands in the cheeks; no pus flowing out from the parotid glands when squeezed; increased serum amylase could contribute to the diagnosis. Efficacy criteria: cure: after 3 treatments, the self-conscious symptoms disappeared within 3 days, and the swelling of parotid gland then subsided; effective: after 3 treatments, the self-conscious symptoms disappeared within 3 days, and the swelling of parotid gland disappeared within 5 days; effective: after 4 treatments, the self-conscious symptoms disappeared within 4 days, and the swelling of parotid gland subsided within 7 days. Results: 29 cases were cured, accounting for 76.3%; 7 cases were effective, accounting for 18.4%; 2 cases were effective, accounting for 5.3%; the total effective rate was 100%.Storage: Seal, keep away from light and place in a cool place (not more than 20ºC).
Address:
Yuexiu District, Guangzhou, Guangdong, China
Business Type:
Manufacturer/Factory
Business Range:
Chemicals, Health & Medicine
Management System Certification:
ISO 9001, GMP
Company Introduction:
ABT is a group company integrating R&D, production and trade, with more than 20 years of global business experience in the pharmaceutical industry. We have an integrated production and trade supply chain from API to preparations, and have the ability to produce and develop impurity cutting- edge biotechnology products; We have an Indian manufacturing supply and sales network and have been committed to the role of a link between Chinese and Indian medicine for mutual development for over 20 years.
Our products contain:
1. Formulation products:
(1) Infusions: Registration in progress and completed, more than 10 countries and regions overseas
(2) Injections: Products are shipped to more than 10 countries and regions
(3) Tablets, capsules: Ultra- low price of Indian raw materials supply, to guarantee our quality, price advantage
2. API and Intermediate: Super low price, quality assurance, direct procurement and delivery from India
3. Impurity: Two laboratories in Guangzhou and Zhengzhou have leading R&D advantages in the industry, with more than 40 R&D personnel
4. Biological products: Hair Growth Promoter; NMN
5. Paper Making Chemical