Basic Info.
Application
Internal Medicine
Suitable for
Elderly, Children, Adult
Pharmaceutical Technology
Chemical Synthesis
Product Name
Galcus Bovis and Metronidazole Capsules
Specification
Metronidazole 0.2g, Galcus Bovis 5mg
Product Description
Product name:Galcus Bovis and Metronidazole CapsulesCharacter:This product is capsule.Main effects:For acute pericoronitis of wisdom teeth, localized alveolar abscess, pulpitis, periapical inflammation, etc.
Usage and Dosage:Take 2 capsules orally, 3 times a day.
Chemical composition:
This product is a compound preparation, its composition is: each capsule contains metronidazole 200mg, artificial oxymoron 5mg.
Drug Interactions:
1. Metronidazole inhibits the metabolism of warfarin and other oral anticoagulants, enhancing their effects and causing prolongation of prothrombin time.
2. Combination with drugs that induce hepatic microsomal enzymes, such as sodium phenytoin and phenobarbital, may enhance the metabolism of this product, resulting in a decrease in blood concentration and a slow excretion of sodium phenytoin.
3. Combined with cimetidine and other drugs that inhibit hepatic microsomal enzyme activity, it may slow down the metabolism of this product in the liver and its excretion, prolonging the blood elimination half-life (t1/2β) of this product, and the dose should be adjusted according to the results of blood concentration measurement.
4. This product can interfere with the metabolism of disulfiram, and when the two are combined, patients may have psychiatric symptoms after drinking alcohol, so it should not be used again if disulfiram is used within 2 weeks.
5. This product can interfere with the results of serum aminotransferase and lactate dehydrogenase, and can cause cholesterol and triacylglycerol levels to decrease.
Pharmacological effects:Metronidazole is a powerful antibacterial agent against most anaerobic bacteria. The antibacterial spectrum includes Bacteroides fragilis and other Bacteroides, Clostridium, Clostridium perfringens, Mycobacterium, Veronococcus, Streptococcus, and others. The bactericidal concentration is slightly higher than the bacteriostatic concentration. The bactericidal mechanism of metronidazole has not been fully elucidated, and the nitroreductase of anaerobic bacteria plays an important role in the energy metabolism of sensitive strains. The nitro reductase of this product becomes a cytotoxic, thus acting on the DNA metabolic process of the bacteria, prompting bacterial death. Drug-resistant bacteria often lack nitroreductase and are therefore resistant to metronidazole. Artificial cowberry has antipyretic and anti-inflammatory effects.
Adverse Reactions:
1. The most serious adverse reactions of this product are seizures and peripheral neuropathy at high doses, the latter mainly manifesting as numbness and abnormal sensation in the extremities. Persistent peripheral neuropathy may develop in some cases with long-term use.
2. Other common adverse reactions are:
(1) Gastrointestinal reactions, such as nausea, loss of appetite, vomiting, diarrhea, abdominal discomfort, altered taste, dry mouth, metallic taste in the mouth, etc.
(2) Reversible granulocytopenia.
(3) Allergic reactions, rash, urticaria, itching, etc.
(4) Central nervous system symptoms, such as headache, vertigo, syncope, abnormal sensation, limb numbness, ataxia and mental confusion.
(5) Others are fever, vaginal Candida infection, cystitis, difficulty in urination, and dark urine, all of which are reversible and recover on their own after stopping the drug.
Taboo:
1. Prohibited in patients with hypersensitivity to metronidazole or pyrroles.
2. Prohibited in patients with active central nervous system disease and hematological disorders.
3. Prohibited in pregnant women.
4. Prohibited in patients who have consumed alcohol.Matters needing attention:
1. Carcinogenic and mutagenic effects: animal tests or in vitro assays found that this product has carcinogenic and mutagenic effects, but it has not been confirmed in humans.
2. If CNS adverse reactions occur during use, the drug should be discontinued promptly.3. This product can interfere with the test results of alanine aminotransferase, lactate dehydrogenase, triacylglycerol, hexokinase, etc. and reduce their measurement values to zero.
4. Alcoholic beverages should not be consumed during medication because they can cause the accumulation of acetaldehyde in the body, interfere with the oxidation process of alcohol and lead to disulfiram-like reactions, and patients may experience abdominal cramps, nausea, vomiting, headache, facial flushing, etc.
5. The metabolism of this product is slowed in people with reduced liver function, and the drug and its metabolites tend to accumulate in the body, so the dosage should be reduced and the blood concentration should be monitored.
6. The product can be continuously cleared from gastric juice, and some people who place gastric tube for suction decompression may cause a decrease in blood concentration. During hemodialysis, the product and its metabolites are rapidly cleared, so no dose reduction is required for this product.
7. Candida infections may be aggravated by the use of this product and require concomitant antifungal treatment.
8. In patients with anaerobic infections combined with renal failure, the dosing interval should be extended from 8 hours to 12 hours.9. Treatment of Trichomonas vaginalis needs to be accompanied by treatment of the sexual partner.
10. A white blood cell count should be done before repeating a course of treatment.Storage:
Shade and store airtight.
Address:
Yuexiu District, Guangzhou, Guangdong, China
Business Type:
Manufacturer/Factory
Business Range:
Chemicals, Health & Medicine
Management System Certification:
ISO 9001, GMP
Company Introduction:
ABT is a group company integrating R&D, production and trade, with more than 20 years of global business experience in the pharmaceutical industry. We have an integrated production and trade supply chain from API to preparations, and have the ability to produce and develop impurity cutting- edge biotechnology products; We have an Indian manufacturing supply and sales network and have been committed to the role of a link between Chinese and Indian medicine for mutual development for over 20 years.
Our products contain:
1. Formulation products:
(1) Infusions: Registration in progress and completed, more than 10 countries and regions overseas
(2) Injections: Products are shipped to more than 10 countries and regions
(3) Tablets, capsules: Ultra- low price of Indian raw materials supply, to guarantee our quality, price advantage
2. API and Intermediate: Super low price, quality assurance, direct procurement and delivery from India
3. Impurity: Two laboratories in Guangzhou and Zhengzhou have leading R&D advantages in the industry, with more than 40 R&D personnel
4. Biological products: Hair Growth Promoter; NMN
5. Paper Making Chemical